The role of the genes of the enzymes of free radical and toxic compounds metabolism in aging and longevity

Owing to the increase of the number of elderly people among the population of the developed countries, the identification of biological and environmental factors contributing to the preservation of their physical and mental activity is of great importance. On the sample of 767 Bashkirs aged from 1 to 105 years old, residents of the Republic of Bashkortostan, the analysis of associations between polymorphic loci of seven genes of the enzymes of free radical and toxic compounds metabolism and the age was performed using PCR method. The frequency of the MSRA*C allele is higher in the group of aging people than in the group of the people aged 1-60 years (p=0,036); the chances of reaching the senile age are increased among carriers of the MSRA*C/C genotype in the age range of 28-75 years (OR=1,048, p=0,038). A decrease of the chances of detecting the CAT*C/C genotype was revealed in the age range up to 70 years (OR=0,979, p=0,028). The NAT2*G/G genotype occurs with a higher frequency among centenarians than in the group of middle-aged people (p=0,04). The frequencies of the SOD1*A allele and the SOD1*A/A genotype are higher among centenarians compared with people of senile age (p=0,05). Polymorphic loci of the SOD1, CAT, MSRA and NAT2 genes can be considered as potential pharmacogenetic markers in the choice of therapy for elderly people.

олголетие, старение, антиоксидантная защита, метаболизм ксенобиотиков, генетический полиморфизм, longevity, aging, antioxidant defense, xenobiotic metabolism, genetic polymorphism