Association of polymorphisms of the KCNQ1 and ADIPOQ genes with the prognosis of type 2 diabetes
https://doi.org/10.25557/2073-7998.2020.05.95-96
Abstract
The aim of this work is study the association of rs2237892 and rs6773957 with T2D in a case-control study. Two groups was formed based on the case - control study. The T2D group is 443 person (mean age 56.2 years, men - 28.8 %, women - 66.2 %), the control group was selected according to the sex and age from the DNA bank of project Health, Alcohol and Psychosocial factors In Eastern Europe (HAPIEE) (n = 532, mean age 56.1 years, men - 33.8 %, women - 66.2 %). DNA was isolated by phenol-chloroform extraction. Genotyping was done by PCR followed by analysis of restriction fragment length polymorphism. Statistical processing was performed using the SPSS 16.0 software package. The genotypes frequencies of rs2237892 of the KCNQ1 gene and rs6773957 of the ADIPOQ gene did not show statistically significant differences. There was no significant effect of rs2237892 of the KCNQ1 gene and rs6773957 of the ADIPOQ gene on the risk of developing type 2 diabetes.
About the Authors
E. S. Mel'nikova
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
O. D. Rymar
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
A. A. Ivanova
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
S. V. Mustafina
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
M. Ju. Shapkina
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
M. . Bobak
Department of Epidemiology & Public Health, University College London
Russian Federation
Russian Federation
S. K. Maljutina
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
M. I. Voevoda
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
V. N. Maksimov
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Review
For citations:
Mel'nikova E.S., Rymar O.D., Ivanova A.A., Mustafina S.V., Shapkina M.J., Bobak M., Maljutina S.K., Voevoda M.I., Maksimov V.N. Association of polymorphisms of the KCNQ1 and ADIPOQ genes with the prognosis of type 2 diabetes. Medical Genetics. 2020;19(5):95-96. (In Russ.) https://doi.org/10.25557/2073-7998.2020.05.95-96
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