Expression of innate immune response genes in the heart valves obtained from patients with infective endocarditis
https://doi.org/10.25557/2073-7998.2020.05.81-82
Abstract
We studied samples of heart valves obtained during cardiac surgery from 26 patients with infective endocarditis (IE) and 12 patients without this pathology (control group). The expression of innate immune response genes (TLR1, TLR2, TLR4 and TLR6) was evaluated by quantitative polymerase chain reaction. It was found that the TLR2 expression in patients with IE was similar to the control group, while the mRNA level of the TLR1, TLR4 and TLR6 genes in the patients was significantly lower compared to the control.
About the Authors
A. V. Tsepokina
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
M. Y. Sinitsky
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
M. A. Asanov
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Y. V. Kazachek
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
A. V. Evtushenko
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
A. V. Ponasenko
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Review
For citations:
Tsepokina A.V., Sinitsky M.Y., Asanov M.A., Kazachek Y.V., Evtushenko A.V., Ponasenko A.V. Expression of innate immune response genes in the heart valves obtained from patients with infective endocarditis. Medical Genetics. 2020;19(5):81-82. (In Russ.) https://doi.org/10.25557/2073-7998.2020.05.81-82
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