Associations of polymorphic variants of the vascular endothelial growth factor А gene with the development of coronary heart disease in Central Russia

M. V. Medvedeva; M. A. Solodilova; M. A. Bykanova; N. V. Ivanova; A. V. Polonikov

doi:10.25557/2073-7998.2020.05.52-53

Associations of polymorphic variants of the vascular endothelial growth factor А gene with the development of coronary heart disease in Central Russia

M. V. Medvedeva, M. A. Solodilova, M. A. Bykanova, N. V. Ivanova, A. V. Polonikov

https://doi.org/10.25557/2073-7998.2020.05.52-53

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Abstract

The contribution of single-nucleotide polymorphisms (SNPs) rs3025039, rs833061, rs3025000 and rs833068 of the VEGF gene to the development of CHD was studied. The Association of rs3025039, rs833061 and rs3025000 with CHD in men was established. The study of haplotypes established associations rs833061T-rs833068A-rs3025000T-rs3025039C and rs833061T-rs833068G-rs3025000C - gs3025039c with a reduced risk of CHD in men, haplotype rs833061C-rs833068G-rs3025000C-rs3025039T and rare haplotypes (frequency <1%) - with an increased risk of CHD in men CHD in women. It was also found that the rs833061T allele is in a negative coupling disequilibrium (LD) with the rs833068G and rs3025000C alleles in men and a positive LD in women, and rs3025039 is in a weak positive LD with the SNP rs3025039 in men.