Search for circular RNAs of the genes involved in lipid metabolism and atherogenesis

Abstract

Non-coding regulatory RNAs are known to affect gene function. We found earlier a negative correlation of high-density lipoprotein cholesterol (HDL-C) with transcripts of some genes involved in HDL metabolism and atherogenesis. In this work, we searched for circular RNA of HDLBP and TNFRSF1A genes in mononuclear cells of patients with different level of HDL-C. The network of competitive interactions of siRNAs with mRNA or circRNA of these genes are predicted by bioinformatic analysis. These circRNAs are suggested to function as the competitive endogenous molecules that are involved in the regulation of gene function.