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Associations of separate working memory parameters with apolipoprotein E gene polymorphism in Siberian adolescents: a population study
https://doi.org/10.25557/2073-7998.2020.04.43-45
Abstract
The APOE gene is one of the most famous genes associated with the development of both cardiovascular diseases and neurodegenerative diseases of the central nervous system, accompanied by impaired cognitive functions. In the course of this study, the associations of APOE gene alleles with cognitive functions violation in the adolescent population of Novosibirsk were studied. The state of cognitive functions was evaluated in 231 boys (42.1%) and 318 girls (57.9%). Their average age was 15.66 ± 0.9 years. It was revealed that the presence of the E4 allele of the APOE gene has a negative effect on the state of working memory even in adolescence.
About the Authors
A. V. Sukhanov
Research Institutе of Internal and Preventive Medicine - Branch of the Federal State Budget Scientific Institution «The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences»
Russian Federation
Russian Federation
A. A. Gurazheva
Research Institutе of Internal and Preventive Medicine - Branch of the Federal State Budget Scientific Institution «The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences»
Russian Federation
Russian Federation
D. V. Denisova
Research Institutе of Internal and Preventive Medicine - Branch of the Federal State Budget Scientific Institution «The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences»
Russian Federation
Russian Federation
V. N. Maksimov
Research Institutе of Internal and Preventive Medicine - Branch of the Federal State Budget Scientific Institution «The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences»
Russian Federation
Russian Federation
Review
For citations:
Sukhanov A.V., Gurazheva A.A., Denisova D.V., Maksimov V.N. Associations of separate working memory parameters with apolipoprotein E gene polymorphism in Siberian adolescents: a population study. Medical Genetics. 2020;19(4):43-45. (In Russ.) https://doi.org/10.25557/2073-7998.2020.04.43-45
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