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<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25557/2073-7998.2020.04.43-45</article-id><article-id custom-type="elpub" pub-id-type="custom">medgen-1149</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF REPORT</subject></subj-group></article-categories><title-group><article-title>Ассоциации отдельных параметров рабочей памяти с полиморфизмом гена аполипопротеина E у сибирских подростков: популяционное исследование</article-title><trans-title-group xml:lang="en"><trans-title>Associations of separate working memory parameters with apolipoprotein E gene polymorphism in Siberian adolescents: a population study</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суханов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sukhanov</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">25081973@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гуражева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gurazheva</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисова</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisova</surname><given-names>D. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimov</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт терапии и профилактической медицины - филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institutе of Internal and Preventive Medicine - Branch of the Federal State Budget Scientific Institution «The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>15</day><month>09</month><year>2020</year></pub-date><volume>19</volume><issue>4</issue><fpage>43</fpage><lpage>45</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Суханов А.В., Гуражева А.А., Денисова Д.В., Максимов В.Н., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Суханов А.В., Гуражева А.А., Денисова Д.В., Максимов В.Н.</copyright-holder><copyright-holder xml:lang="en">Sukhanov A.V., Gurazheva A.A., Denisova D.V., Maksimov V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/1149">https://www.medgen-journal.ru/jour/article/view/1149</self-uri><abstract><p>Ген APOE - это один из наиболее известных генов, ассоциированных с развитием как сердечно-сосудистых, так и нейродегенеративных заболеваний центральной нервной системы, сопровождающихся нарушением когнитивных функций (КФ). В ходе настоящего исследования изучены ассоциации аллелей гена APOE с нарушением КФ у подростков г. Новосибирска. Состояние КФ было оценено у 231 мальчика (42,1%) и у 318 девочки (57,9%). Их средний возраст составил 15,66 ± 0,9 года. Выявлено, что наличие аллеля Е4 оказывает негативное влияние на состояние рабочей памяти уже в подростковом возрасте.</p></abstract><trans-abstract xml:lang="en"><p>The APOE gene is one of the most famous genes associated with the development of both cardiovascular diseases and neurodegenerative diseases of the central nervous system, accompanied by impaired cognitive functions. In the course of this study, the associations of APOE gene alleles with cognitive functions violation in the adolescent population of Novosibirsk were studied. The state of cognitive functions was evaluated in 231 boys (42.1%) and 318 girls (57.9%). Their average age was 15.66 ± 0.9 years. It was revealed that the presence of the E4 allele of the APOE gene has a negative effect on the state of working memory even in adolescence.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>оперативная память</kwd><kwd>подростки</kwd><kwd>тест Лурия</kwd><kwd>тест называния животных</kwd><kwd>методика исключения понятий</kwd><kwd>ген аполипопротеина E</kwd><kwd>working memory</kwd><kwd>adolescents</kwd><kwd>Luria’s 10-words test</kwd><kwd>animal naming test</kwd><kwd>test of excluded of incorrect words</kwd><kwd>apolipoprotein E gene</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
