Studying the main effect and the effect of gene-gene interactions in the formation of individual differences in the level of cognitive function

Abstract

The difficulties frequently caused by the presence of high stress sensitivity during performing mathematical operations (mathematical anxiety, MA) in a modern high-tech society represent the important problem for both individual success and economic well-being of a society. We analyzed the interaction of 23 polymorphic variants of genes responsible for the regulation of neurotransmitter systems, working memory and synaptic plasticity, in determining inter-individual differences in the level of mathematical anxiety. As a result, we obtained two optimal statistical models of intergenic interactions associated with the level of mathematical anxiety (СREB1 (rs35349697) x DTNBP1 (rs2619522) and DRD2 (rs6277) x ВDNF (rs6265)).