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Quantitative distribution of risk genotypes for schizophrenia patients withantipsychotic-induced extrapyramidal symptoms in Belarusian population
https://doi.org/10.25557/2073-7998.2020.04.22-23
Abstract
Investigation of genetic predictors of antipsychotic-inducedextrapyramidal symptoms and search for usage algorithms will help treatment optimization and personalization. There was a significant association (χ2=41,6; р=0,0000001) of antipsychotic-induced extrapyramidal symptoms with quantitative distribution of risk Del-/GSTM1; Del-/ GSTT1; A2A2/rs1800497; AG/rs3892097; TT/rs1045642 genotypes from 0 to 5. The safety of antipsychotic treatment least requires genotyping of DRD2 and GSTM1 genes as well as individual selection of antipsychotics for patients with three or more risk genotypes.
About the Authors
I. M. Halayenka
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus
Russian Federation
Russian Federation
V. G. Objedkov
Belarusian Medical State University
Russian Federation
Russian Federation
O. V. Gorgun
Belarusian Medical State University
Russian Federation
Russian Federation
O. D. Levdansky
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus
Russian Federation
Russian Federation
O. G. Davydenko
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus
Russian Federation
Russian Federation
Review
For citations:
Halayenka I.M., Objedkov V.G., Gorgun O.V., Levdansky O.D., Davydenko O.G. Quantitative distribution of risk genotypes for schizophrenia patients withantipsychotic-induced extrapyramidal symptoms in Belarusian population. Medical Genetics. 2020;19(4):22-23. (In Russ.) https://doi.org/10.25557/2073-7998.2020.04.22-23
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