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Genetic variants of the TCF4, LSM1, and CCDC60 genes are associated with schizophrenia
https://doi.org/10.25557/2073-7998.2020.04.17-19
Abstract
1020 DNA samples of two groups of people (schizophrenia and control) from the Russian population were analyzed using 30 SNPs. As the analyzed markers, SNPs were selected that showed an association with schizophrenia or variability of cognitive abilities in genome-wide association studies. Multiplex genotyping was performed using the MassARRAY System 4 platform. As a result of the analysis, statistically significant associations were revealed for polymorphic variants of the TCF4, LSM1, CCDC60 genes. Our results confirm the role of the TCF4 and LSM1 genes in the schizophrenia pathogenesis in world populations.
About the Authors
A. V. Bocharova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. V. Marusin
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
S. A. Ivanova
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
O. U. Fedorenko
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. V. Semke
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
V. A. Stepanov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
Review
For citations:
Bocharova A.V., Marusin A.V., Ivanova S.A., Fedorenko O.U., Semke A.V., Stepanov V.A. Genetic variants of the TCF4, LSM1, and CCDC60 genes are associated with schizophrenia. Medical Genetics. 2020;19(4):17-19. (In Russ.) https://doi.org/10.25557/2073-7998.2020.04.17-19
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