Polymorphisms of endothelin-1 system genes and risk of essential hypertension
https://doi.org/10.1234/XXXX-XXXX-2015-10-29-35
Abstract
Endothelin-1 system plays an important role in regulation of vascular tone and vascular remodeling. The aim of the current study was to perform an analysis of association between essential hypertension and polymorphic variants in genes, encoding endothelin-1, endothelin-converting enzyme, endothelin receptors A and B, in the ethnic group of Tatars residing in the Republic of Bashkortostan. We found an association of EDNRA rs6842241 and EDNRB rs5351 polymorphic variants with essential hypertension in men. Furthermore, an increased risk of essential hypertension was detected for the carriers of EDNRA *G/G genotype and EDNRB *C allele combination, while EDNRA *C and EDNRB *A alleles combination had protective effect against the development of the disease.
About the Authors
Y. R. Timasheva
Institute if Biochemistry and Genetics of Ufa Scientific Centre of Russian Academy of Sciences
Russian Federation
Russian Federation
T. R. Nasibullin
Institute if Biochemistry and Genetics of Ufa Scientific Centre of Russian Academy of Sciences
Russian Federation
Russian Federation
E. B. Imaeva
Institute if Biochemistry and Genetics of Ufa Scientific Centre of Russian Academy of Sciences
Russian Federation
Russian Federation
G. Kh. Mirsaeva
Bashkir State Medical University
Russian Federation
Russian Federation
O. E. Mustafina
Institute if Biochemistry and Genetics of Ufa Scientific Centre of Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Timasheva Y.R., Nasibullin T.R., Imaeva E.B., Mirsaeva G.Kh., Mustafina O.E. Polymorphisms of endothelin-1 system genes and risk of essential hypertension. Medical Genetics. 2015;14(10):29-35. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2015-10-29-35
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