Analysis of TNNT2 polymorphism associations with echocardiographic parameters in shift workers with hypertension in the Arctic area

Shift work is a significant risk factor for human maladaptation and early myocardial remodeling. The prevalence of hypertension (HTN) is 47% among men with shift work in the Arctic. Hypertension quickly harms vital organs and can lead to heart failure. An association between TNNT2 gene polymorphisms and echocardiographic parameters was previously reported in patients with hypertrophic cardiomyopathy. Objective: To examine associations between common genetic variants of the TNNT2 gene and echocardiographic parameters in shift workers with HTN in the Arctic area. A total of 190 males (18-70 years old) were included. DNA samples were genotyped using a real-time polymerase chain reaction. As a result, rs1104859, rs3729547, and rs10920184 demonstrated a statistically significant association with several echocardiographic parameters (left atrial strain, posterior wall thickness, left ventricular volume, and interventricular septal thickness). This suggests the potential for using genotyping to predict the clinical course of early myocardial remodeling in shift workers with HTN in Arctic area.

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