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Application of bacterial test systems and C. elegans nematodes for studying the genotoxicity of the photosensitizer 8-methoxypsoralen
https://doi.org/10.25557/2073-7998.2025.11.130-131
Abstract
The lux-test method showed that the combined effect of 8-methoxypsoralen (8-MOP) and UV irradiation leads to an increase in the luminescence of lux-biosensors by 3-40 times compared to the control. The nematode test confirmed the hypothesis of induction of active oxygen species (AOS) in eukaryotes when exposed to 8-MOP in combination with UV irradiation.
Keywords
8-methoxypsoralen,
lux-test,
biosensors,
luminescence,
ultraviolet radiation,
repair,
SOS response,
active oxygen species
Supporting agencies: State assignment 125091010190-9
About the Authors
Y. Hu
M.V. Lomonosov Moscow State University
Russian Federation
Russian Federation
GSP-1, Leninskie Gory, Moscow, 119991
E. V. Igonina
Vavilov Institute of General Genetics Russian Academy of Sciences
Russian Federation
Russian Federation
3, Gubkina st., Moscow, 119333
A. V. Shibaeva
Emanuel Institute of Biochemical Physics of RAS
Russian Federation
Russian Federation
4, Kosygina st., Moscow, 119334
S. K. Abilev
M.V. Lomonosov Moscow State University; Vavilov Institute of General Genetics Russian Academy of Sciences
Russian Federation
Russian Federation
GSP-1, Leninskie Gory, Moscow, 119991; 3, Gubkina st., Moscow, 119333
References
1. Igonina E.V., Marsova M.V., Abilev S.K. Lux-biosensory: skrining biologicheski aktivnykh soyedineniy na genotoksichnost’ [Luxbiosensors: screening biologically active compounds for genotoxicity]. Ekologicheskaya genetika [Ecological genetics] 2016;14(4):52-62. (In Russ.) doi: 10.17816/ecogen14452-62
2. Abilev S.K., Igonina E.V., Sviridova D.A., Smirnova S.V. Bacterial Lux Biosensors in Genotoxicological Studies. Biosensors, 2023; (13): 511.
Review
For citations:
Hu Y., Igonina E.V., Shibaeva A.V., Abilev S.K. Application of bacterial test systems and C. elegans nematodes for studying the genotoxicity of the photosensitizer 8-methoxypsoralen. Medical Genetics. 2025;24(11):130-131. (In Russ.) https://doi.org/10.25557/2073-7998.2025.11.130-131
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