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Study on the relationship between glutathione synthetase gene polymorphisms and the risk of coronary artery disease
https://doi.org/10.25557/2073-7998.2025.11.112-113
Abstract
The aim of this study was to investigate the relationship between three functionally significant single nucleotide polymorphisms (SNPs) rs7265992, rs6088660, and rs1801310 of the GSS gene and the risk of coronary heart disease (CHD). The findings indicated that the rs7265992 and rs6088660 polymorphisms were associated with a reduced risk of CHD, whereas the rs1801310 variant was associated with an increased risk of developing the disease. Stratified analysis by gender revealed that the rs1801310 polymorphism of the GSS gene was linked to an increased risk of CHD only in men. This study establishes for the first time that polymorphic variants of the glutathione synthetase gene are associated with a predisposition to coronary heart disease.
Keywords
ischemic heart disease,
hereditary predisposition,
glutathione metabolism,
glutathione synthetase,
single nucleotide polymorphism (SNP)
Supporting agencies: The work was carried out with the financial support of the Russian Science Foundation (project No. 25-25-20086) and the Ministry of Education and Science of the Kursk Region
About the Authors
E. S. Sokolnikova
Kursk State Medical University
Russian Federation
Russian Federation
3, K. Marx st., Kursk, 305041
Iu. E. Azarova
Kursk State Medical University
Russian Federation
Russian Federation
3, K. Marx st., Kursk, 305041
O. Yu. Bushueva
Kursk State Medical University
Russian Federation
Russian Federation
3, K. Marx st., Kursk, 305041
A. V. Polonikov
Kursk State Medical University
Russian Federation
Russian Federation
3, K. Marx st., Kursk, 305041
References
1. Wu G., Fang Y.Z., Yang S., et al. Glutathione metabolism and its implications for health. J Nutr. 2004;134(3):489-92.
2. Matuz-Mares D., Riveros-Rosas H., Vilchis-Landeros M.M., Vázquez-Meza H. Glutathione Participation in the Prevention of Cardiovascular Diseases. Antioxidants (Basel). 2021;10(8):1220.
3. Rom O., Liu Y., Finney A.C., et al. Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis. Redox Biol. 2022;52:102313.
4. Malekmohammad K., Sewell R.D.E., Rafieian-Kopaei M. Antioxidants and Atherosclerosis: Mechanistic Aspects. Biomolecules. 2019 ;9(8):301.
Review
For citations:
Sokolnikova E.S., Azarova I.E., Bushueva O.Yu., Polonikov A.V. Study on the relationship between glutathione synthetase gene polymorphisms and the risk of coronary artery disease. Medical Genetics. 2025;24(11):112-113. (In Russ.) https://doi.org/10.25557/2073-7998.2025.11.112-113
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