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Study of the effect of spermidine on the genotoxicity of dioxidine and hydrogen peroxide using sensory strains of Escherichia coli
https://doi.org/10.25557/2073-7998.2025.11.109-111
Abstract
The effect of spermidine on the DNA-damaging effect of dioxidine and hydrogen peroxide was studied on the cells of the lux-biosensors E. coli MG1655 (pColD-lux) and (pKatG-lux), luminescent as a result of activation of the promoters of the colicin colD and catalase katG genes. It was shown that spermidine reduces the genotoxic effect induced by the studied drugs by 40 and 23% in E. coli cells, and also reduces the number of DNA breaks.
Supporting agencies: The work was carried out within the framework of the State assignment Р125091010190-9
About the Authors
S. V. Smirnova
Vavilov Institute of General Genetics of Russian Academic Science
Russian Federation
Russian Federation
3, Gubkina st., Moscow, 119991
E. V. Trofimentseva
Vavilov Institute of General Genetics of Russian Academic Science
Russian Federation
Russian Federation
3, Gubkina st., Moscow, 119991
S. K. Abilev
Vavilov Institute of General Genetics of Russian Academic Science
Russian Federation
Russian Federation
3, Gubkina st., Moscow, 119991
References
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Review
For citations:
Smirnova S.V., Trofimentseva E.V., Abilev S.K. Study of the effect of spermidine on the genotoxicity of dioxidine and hydrogen peroxide using sensory strains of Escherichia coli. Medical Genetics. 2025;24(11):109-111. (In Russ.) https://doi.org/10.25557/2073-7998.2025.11.109-111
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