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Haplotype frequencies of polymorphic variants of the NFKB1 gene in pulmonary tuberculosis
https://doi.org/10.25557/2073-7998.2025.11.93-95
Abstract
The NF-kB signaling pathway is one of their key mechanisms that trigger the synthesis of pro-inflammatory factors in response to infection with pathogens. The data on the study of haplotype frequencies of the NFKB1 gene by a panel of polymorphic variants are discussed: rs28362491, rs160993, rs4648050, rs4648051, rs4648055, rs4648058, rs4648068 in a sample of patients with pulmonary tuberculosis (TB, n=169) and in the population control group (PC, n=96). DNA isolated from blood samples using phenol-chloroform extraction, genotyped by real-time PCR. 49 haplotypic variants were identified in the group of patients, 33 in the control group. The spectrum and frequency of major haplotypes were determined: in the TB group – DCCGACG, ICTAGGA with a total frequency of 43%; in the PC sample – DCCGACG, ICTAGGA, ICTAGCA and DCCGAGG (a total frequency of 60%).
Supporting agencies: The study was conducted within the framework of the basic budgetary funding source for project of the State Assignment of the Ministry of Health of the Russian Federation (agreement No. 056-03-2023-050 dated 17.01.2023)
About the Authors
A. V. Meyer
Kemerovo State Medical University
Russian Federation
Russian Federation
22a, Voroshilova st., Kemerovo, 650056
B. A. Thorenko
Kemerovo State Medical University
Russian Federation
Russian Federation
22a, Voroshilova st., Kemerovo, 650056
D. O. Imekina
Kemerovo State Medical University
Russian Federation
Russian Federation
22a, Voroshilova st., Kemerovo, 650056
K. B. Karabchukov
Kemerovo State Medical University
Russian Federation
Russian Federation
22a, Voroshilova st., Kemerovo, 650056
M. B. Lavryashina
Kemerovo State Medical University
Russian Federation
Russian Federation
22a, Voroshilova st., Kemerovo, 650056
References
1. Mitchell S., Vargas J., Hoffmann A. Signaling via the NFκB system. Wiley Interdiscip Rev Syst Biol Med. 2016;8(3):227–41. doi: 10.1002/wsbm.1331.
2. Moorthy A.K., Savinova O.V., Ho J.Q., et al. The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner. EMBO J. 2006;25(9):1945–56. doi: 10.1038/sj.emboj.7601081
Review
For citations:
Meyer A.V., Thorenko B.A., Imekina D.O., Karabchukov K.B., Lavryashina M.B. Haplotype frequencies of polymorphic variants of the NFKB1 gene in pulmonary tuberculosis. Medical Genetics. 2025;24(11):93-95. (In Russ.) https://doi.org/10.25557/2073-7998.2025.11.93-95
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