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Study of the role of the BDNF gene in the formation of differences in the level of state trait anxiety
https://doi.org/10.25557/2073-7998.2025.11.60-62
Abstract
The study is devoted to investigating the genetic predisposition to anxiety disorders, particularly the role of the BDNF (brain-derived neurotrophic factor) gene in the formation of state and trait anxiety. The work analyzed data from 333 mentally healthy students from the Republic of Bashkortostan. Methods of genetic analysis (PCR, fluorescence detection) and psychometric testing (Spielberger-Hanin questionnaire) were used. The results revealed significant associations of the polymorphic loci rs6265 and rs712442 of the BDNF gene with variations in anxiety levels. The rs6265A allele was associated with lower levels of trait anxiety (β = -1.748; p = 0.02), while the rs712442T allele was linked to higher levels of state anxiety (β = 1.27; p = 0.03). Additionally, gene-environment interactions between BDNF polymorphisms and the history of COVID-19 were found to influence state anxiety levels. Differences in anxiety were also identified based on gender, maternal age at childbirth, birth weight, antibiotic use, and hormone therapy. The findings emphasize the importance of a comprehensive approach to studying anxiety, considering both genetic and environmental factors.
Supporting agencies: This research received no external funding
About the Authors
R. F. Enikeeva
Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences; Ufa University of Science and Technology
Russian Federation
Russian Federation
71, Prospekt Oktyabrya, Ufa, 450054; 32, Zaki Validi st., Ufa, 450076
A. V. Kazantseva
Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences; Ufa University of Science and Technology; Ufa State Petroleum Technological University
Russian Federation
Russian Federation
71, Prospekt Oktyabrya, Ufa, 450054; 32, Zaki Validi st., Ufa, 450076; 1, Kosmonavtov st., Ufa, 450044
Yu. D. Davydova
Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
71, Prospekt Oktyabrya, Ufa, 450054
R. N. Mustafin
Bashkir State Medical University
Russian Federation
Russian Federation
3, Lenina st., Ufa, 450008
A. R. Romanova
Bashkir State Medical University
Russian Federation
Russian Federation
3, Lenina st., Ufa, 450008
M. M. Lobaskova
Psychological Institute of the Russian Academy of Education
Russian Federation
Russian Federation
9/4, Mokhovaya st., Moscow, 125009; GSP-1, Moscow, 119991
S. B. Malykh
Psychological Institute of the Russian Academy of Education; M.V. Lomonosov Moscow State University Leninskie Gory
Russian Federation
Russian Federation
9/4, Mokhovaya st., Moscow, 125009;
GSP-1, Moscow, 119991
E. V. Gabdrakhmanova
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
E. I. Khusainova
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
E. K. Khusnutdinova
Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences; Ufa University of Science and Technology; M.V. Lomonosov Moscow State University Leninskie Gory
Russian Federation
Russian Federation
71, Prospekt Oktyabrya, Ufa, 450054; 32, Zaki Validi st., Ufa, 450076; GSP-1, Moscow, 119991
References
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Review
For citations:
Enikeeva R.F., Kazantseva A.V., Davydova Yu.D., Mustafin R.N., Romanova A.R., Lobaskova M.M., Malykh S.B., Gabdrakhmanova E.V., Khusainova E.I., Khusnutdinova E.K. Study of the role of the BDNF gene in the formation of differences in the level of state trait anxiety. Medical Genetics. 2025;24(11):60-62. (In Russ.) https://doi.org/10.25557/2073-7998.2025.11.60-62
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