Polymorphic variants of DNAJA3 and DNAJB2 genes are associated with age of ischemic stroke manifestation, level of total cholesterol and hemocoagulation parameters

Abstract

Despite extensive worldwide studies of heat shock proteins (HSP) in risk of ischemic stroke (IS), the role of the HSP40 family remains virtually unexplored. Thus, the aim of this work was to study the association of polymorphic variants of the HSP40 genes with clinical parameters of patients with IS. Genotyping of 1306 patients with IS was performed using real-time PCR and the MassArray-4 system. It was observed that rs6500605 DNAJA3 is associated with an earlier age of IS manifestation (β = -1,33±0,64, P perm = 0,03) and a lower level of total cholesterol in the blood (β = -0,42±0,54, P perm = 0,02); rs3731896 DNAJB2 is associated with a decrease in the prothrombin index (PTI) (β = -2,31±0,87, P perm = 0,008) and international normalized ratio (INR) (β = -0,10±0,049, P perm = 0,045). Thus, polymorphic variants of the genes encoding heat shock proteins HSP40 affect the clinical parameters of patients with IS.