Generate QR code
Open Access
Subscription Access
Analysis of association of polymorphic loci rs1625895 и rs1042522 of gene TP53 with the risk of developing ovarian cancer
https://doi.org/10.25557/2073-7998.2025.10.43-44
Abstract
Background: Ovarian cancer remains one of the most common causes of death from gynecological cancer in women worldwide. Aim: analysis of the association of polymorphic loci of the rs1625895 и rs1042522 of gene TP53 with the risk of developing ovarian cancer. Material: DNA samples isolated from the peripheral blood of 239 patients with ovarian cancer and 271 conditionally healthy women. Method: PCR-RFLP analysis and real-time PCR. As a result of study, we did not find an association of polymorphic loci rs1625895 and rs1042522 of the TP53 gene with the risk of developing ovarian cancer.
About the Authors
E. T. Aminova
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
Yu. Yu. Fedorova
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
E. A. Andreeva
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
Ya. V. Valova
Ufa University of Science and Technology ; Ufa Research Institute of Occupational Health and Human Ecology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
94, Stepana Kuvykina st., Ufa, 450106
A. Kh. Nurgalieva
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
R. R. Faishkhanova
Republican Clinical Oncological Dispensary
Russian Federation
Russian Federation
73/1, Pr. Oktyabrya., Ufa, 450054
I. R. Zagitov
Republican Clinical Oncological Dispensary
Russian Federation
Russian Federation
73/1, Pr. Oktyabrya., Ufa, 450054
A. R. Romanova
Bashkir State Medical University
Russian Federation
Russian Federation
3, Lenina st., Ufa, 450008
D. D. Sakaeva
Bashkir State Medical University
Russian Federation
Russian Federation
3, Lenina st., Ufa, 450008
E. K. Khusnutdinova
Ufa University of Science and Technology ; Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
71, Pr. Oktyabrya, Ufa, 450054
D. S. Prokofieva
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
References
1. Floris M., Pira G., Castiglia P., et al. Impact on breast cancer susceptibility and clinicopathological traits of common genetic polymorphisms in TP53, MDM2 and ATM genes in Sardinian women. Oncol Lett. 2022;24(4):331.
2. Yu M., Zhang Q., Zhao X. Associations of MDM2 rs2279744 and TP53 rs1042522 polymorphisms with cervical cancer risk: A metaanalysis and systematic review. Front Oncol. 2022;12:973077.
Review
For citations:
Aminova E.T., Fedorova Yu.Yu., Andreeva E.A., Valova Ya.V., Nurgalieva A.Kh., Faishkhanova R.R., Zagitov I.R., Romanova A.R., Sakaeva D.D., Khusnutdinova E.K., Prokofieva D.S. Analysis of association of polymorphic loci rs1625895 и rs1042522 of gene TP53 with the risk of developing ovarian cancer. Medical Genetics. 2025;24(10):43-44. (In Russ.) https://doi.org/10.25557/2073-7998.2025.10.43-44
Views:
9
Email this article 