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Aberrant methylation of microRNA genes in ovarian cancer
https://doi.org/10.25557/2073-7998.2025.09.101-102
Abstract
The discovery of microRNA (miRNA) provides a new and powerful tool for studying malignant tumors of various localizations. Objective: to study aberrant methylation of individual miRNA genes in ovarian cancer (OC). Material: 25 paired samples (tumor/norm) of OC, as well as 15 control ovarian tissue samples. Methods: MS-HRM analysis. We have obtained for the first-time information on the methylation level of miRNA genes miR-663a and miR-663b in OC. The results of the study indicate a specific involvement of miRNA genes miR-663a and miR-127 in the pathogenesis of OC.
Supporting agencies: The work was carried out with the financial support of the Russian Science Foundation (agreement No. 23-24-00452 dated 13.01.23) and the state assignment of the Ministry of Science and Higher Education of the Russian Federation (agreement No. 075-03-2024-123/1).
About the Authors
D. S. Prokofyeva
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
Yu. Yu. Fedorova
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
E. T. Aminova
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
A. Kh. Nurgalieva
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
E. A. Andreeva
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
D. D. Sakaeva
Bashkir State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
3, Lenina st., Ufa, 450008
R. R. Faishkhanova
Republican Clinical Oncology Dispensary
Russian Federation
Russian Federation
73/1, Prospekt Oktyabrya, Ufa, 450054
I. R. Zagitov
Republican Clinical Oncology Dispensary
Russian Federation
Russian Federation
73/1, Prospekt Oktyabrya, Ufa, 450054
E. K. Khusnutdinova
Ufa University of Science and Technology; Bashkir State Medical University of the Ministry of Health of the Russian Federation;
Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076; 3, Lenina st., Ufa, 450008; 71, Prospekt Oktyabrya, Ufa, 450054
References
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Review
For citations:
Prokofyeva D.S., Fedorova Yu.Yu., Aminova E.T., Nurgalieva A.Kh., Andreeva E.A., Sakaeva D.D., Faishkhanova R.R., Zagitov I.R., Khusnutdinova E.K. Aberrant methylation of microRNA genes in ovarian cancer. Medical Genetics. 2025;24(9):101-102. (In Russ.) https://doi.org/10.25557/2073-7998.2025.09.101-102
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