IL20RB and SELENOP expression in peripheral blood leukocytes of patients with chronic pulmonary sarcoidosis

Abstract

This study aimed to investigate the expression of IL20RB and SELENOP genes in peripheral blood leukocytes (PBL) of patients with pulmonary sarcoidosis. Fifty-two people were enrolled in our study, 24 of whom were patients (average age 42.11±2.21 years) with an established diagnosis of pulmonary sarcoidosis, chronic course, stage II, not receiving therapy. The diagnosis was established in accordance with the criteria based on clinical, radiological and laboratory changes with histological verification of the biopsy study. The control group was formed by 28 conditionally healthy donors (average age 43.03±1.84 years). The level of IL20RB, SELENOP gene transcripts in the studied groups was estimated by real-time PCR. According to our data, the level of IL20RB gene mRNA expression in PBL of patients with pulmonary sarcoidosis was lower compared to the control (p=0.0001). The number of SELENOP gene transcripts was significantly different from the values in the control group (p=0,0004). The results of the study may indicate the probable involvement of this genes in the pathogenesis of pulmonary sarcoidosis.