CETP gene polymorphism in Siberian populations

   The present study was carried out within the framework of an actual direction, the task of which is to study the peculiarities of the population-genetic structure of the indigenous peoples of Siberia in genogeographical and biomedical aspects.

   The aim was to identify ethnic peculiarities in the distribution of polymorphic variants of the CETP gene (G1264A, rs5882) in Siberian populations.

   Using realtime PCR, the frequencies of the CETP 1264G allele associated with favorable blood lipid parameters were determined in samples of Yakuts, Dolgans, Nganasans, Tuvinians, Kazakhs of Altai, and Russians of Siberia. The increased frequency of the CETP 1264G allele in Tuvinians (48.5 %) compared to Caucasians was shown to be close to that in East Asian populations, while in Dolgans it was statistically significantly lowest (21.5 %) compared to the majority of the studied ethnic groups. The other samples do not have significant differences from the groups of Europeans described in the literature; however, Yakuts (27.3 % and 31.8 %), Nganasans (35.6 %), Kazakhs (31.4 %), and Russians (30.7 %) are statistically significantly separated from populations in China and Japan by lower CETP 1264G frequency values. In general, indigenous Siberian populations are intermediate between Caucasoid groups and East Asian populations in terms of CETP 1264G allele frequency. A high frequency of the CETP 1264G allele in Tuvinians was shown, while in the Dolgan population it is the lowest, which may indicate an increased risk of atherosclerosis.

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