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A study on the association between the single nucleotide polymorphisms rs17293632 and rs2033784 of the SMAD3 gene and the risk of bronchial asthma in children from the Kursk region
https://doi.org/10.25557/2073-7998.2025.08.114-116
Abstract
Various smooth muscle-specific genes and proteins, including SMAD3, play a crucial role in airway remodeling associated with bronchial asthma (BA), significantly impacting the pathogenesis of this condition. Our study revealed that both single nucleotide polymorphisms (SNPs) in the general population were linked to an increased risk of developing BA. Specifically, rs17293632 was associated with a p-value of 6.0 × 10-4, and rs2033784 had a p-value of 0.0019. Additionally, we identified an association between the rs17293632 polymorphism and the risk of developing BA in girls, with a p-value of 2.0 × 10-4. The influence of the rs2033784 polymorphism on the increased risk of developing BA in girls was also confirmed, with a p-value of 6.0 × 10-4.
Supporting agencies: The study was carried out with the support and funding of Kursk State Medical University
About the Authors
A. V. Serezhkina
Kursk State Medical University
Russian Federation
Russian Federation
Alexandra V. Serezhkina
305041; 3, K. Marx st,; Kursk
O. Yu. Bushueva
Kursk State Medical University
Russian Federation
Russian Federation
305041; 3, K. Marx st,; Kursk
P. K. Sunyakina
Kursk State Medical University
Russian Federation
Russian Federation
305041; 3, K. Marx st,; Kursk
A. D. Bogomazov
Kursk State Medical University
Russian Federation
Russian Federation
305041; 3, K. Marx st,; Kursk
A. V. Polonikov
Kursk State Medical University
Russian Federation
Russian Federation
305041; 3, K. Marx st,; Kursk
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Review
For citations:
Serezhkina A.V., Bushueva O.Yu., Sunyakina P.K., Bogomazov A.D., Polonikov A.V. A study on the association between the single nucleotide polymorphisms rs17293632 and rs2033784 of the SMAD3 gene and the risk of bronchial asthma in children from the Kursk region. Medical Genetics. 2025;24(8):114-116. (In Russ.) https://doi.org/10.25557/2073-7998.2025.08.114-116
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