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Analysis of the patterns of combinations of polymorphic variants in redox homeostasis genes associated with aging and longevity
https://doi.org/10.25557/2073-7998.2025.08.92-93
Abstract
The aim of the study was to identify associations with aging and longevity of combinations of polymorphic DNA loci in genes regulating cellular redox balance.
It was found that combinations of alleles and genotypes of SOD2 (rs4880), GPX4 (rs713041), GSTP1 (rs1695) and KEAP1 (rs1048290) are associated with old age in men, while combinations of SOD2, KEAP1, NFE2L2 (rs6721961) and AKT1 (rs3803304) are associated with reduced chances of longevity.
Keywords
Supporting agencies: This study was supported by the Russian Science Foundation (Grant no. 24-25-00179, https://rscf.ru/project/24-25-00179/)
About the Authors
A. A. Petintseva
Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
Russian Federation
Russian Federation
Anna A. Petintseva
450054; 71, October prospect; Ufa
T. R. Nasibullin
Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
Russian Federation
Russian Federation
450054; 71, October prospect; Ufa
I. A. Tuktarova
Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
Russian Federation
Russian Federation
450054; 71, October prospect; Ufa
Ya. R. Timasheva
Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Bashkir State Medical University
Russian Federation
Russian Federation
450054; 71, October prospect; 450008; 3, Lenina st.; Ufa
V. V. Erdman
Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Bashkir State Medical University
Russian Federation
Russian Federation
450054; 71, October prospect; 450008; 3, Lenina st.; Ufa
References
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Review
For citations:
Petintseva A.A., Nasibullin T.R., Tuktarova I.A., Timasheva Ya.R., Erdman V.V. Analysis of the patterns of combinations of polymorphic variants in redox homeostasis genes associated with aging and longevity. Medical Genetics. 2025;24(8):92-93. (In Russ.) https://doi.org/10.25557/2073-7998.2025.08.92-93
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