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Relationship of pharmacoresistance, dose of antipsychotics and polymorphic gene loci CYP2D6, CYP1A2, MDR1, SLC6A4 in patients with schizophrenia
https://doi.org/10.25557/2073-7998.2025.08.43-45
Abstract
The pharmacogenetic characteristics of the patient may determine his individual therapeutic concentration, at which the drug provides effective clinical treatment without significant side effects. A relationship was found between the occurrence of polymorphic alleles A-/rs3892097; A-/rs762551;T-/rs1045642; S-/5-HTTLPR, antipsychotic dose, and pharmacoresistance in patients with schizophrenia. The effectiveness of antipsychotic therapy in some cases is based on an individual choice of medication and dose, taking into account the results of genetic testing.
Supporting agencies: The work was carried out within the framework of activities for scientific support of the State Program «Public Health and Demographic Security» for 2021-2025, subprogram «Prevention and Overcoming of Drunkenness and Alcoholism, Protection of Mental Health»
About the Authors
I. M. Halayenka
Republican Research and Practice Center for Mental Health
Belarus
Belarus
Inesа Mikhailauna Halayenka
220053; 152, Dolginovsky tract; Minsk
T. S. Golubeva
Republican Research and Practice Center for Mental Health
Belarus
Belarus
220053; 152, Dolginovsky tract; Minsk
Yu. M. Kaminskaya
Republican Research and Practice Center for Mental Health
Belarus
Belarus
220053; 152, Dolginovsky tract; Minsk
G. V. Sergeev
Institute of Bioorganic Chemistry of National Academy of Sciences of Belarus
Belarus
Belarus
220141; 5/2, akad. Kuprevicha st.; Minsk
V. G. Objedkov
Republican Research and Practice Center for Mental Health
Belarus
Belarus
220053; 152, Dolginovsky tract; Minsk
References
1. Halayenka I. M., Obyedkov V. G., Golubeva T. S. et al. Relevance of pharmacogenetic testing in the antipsychotic therapy of schizophrenia. Molecular and Applied Genetics: Proccedings. Institute of Genetics and Cytology of the National Academy of Sciences of Belarus. 2023;(34):121-132. (In Russ.)
2. Ji X., Ning B., Liu J. et al. Towards population-specific pharmacogenomics in the era of next-generation sequencing. Drug Discovery Today. 2021;26(8):1776-1783.
3. Patel R.A., Musharoff S.A., Spence J.P. et al. Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits. Am. J. Hum. Genet. 2022; 109(7):1286-1297.
Review
For citations:
Halayenka I.M., Golubeva T.S., Kaminskaya Yu.M., Sergeev G.V., Objedkov V.G. Relationship of pharmacoresistance, dose of antipsychotics and polymorphic gene loci CYP2D6, CYP1A2, MDR1, SLC6A4 in patients with schizophrenia. Medical Genetics. 2025;24(8):43-45. (In Russ.) https://doi.org/10.25557/2073-7998.2025.08.43-45
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