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Polymorphism of genes involved in vitamin D metabolism and inflammatory response in patients with coronary artery disease
https://doi.org/10.25557/2073-7998.2025.07.116-118
Abstract
This study is aimed to the investigation of associations between the vitamin D metabolism genes polymorphism and inflammatory response with their soluble forms in patients with stable coronary artery disease (CAD). The obtained results indicate the association of polymorphic variants rs16944 (IL1b), rs3093077 (CRP) and rs731236 (VDR) with the CAD risk. In addition, it is noted that high levels of soluble CRP are associated with the genotypes of the rs3093077 polymorphism.
Supporting agencies: This research was supported by the Complex Program of Fundamental Research of the Siberian Branch of the Russian Academy of Sciences within the framework of the fundamental research project of the Research Institute for Complex Issues of Cardiovascular Diseases No. 0419-2022-0002.
About the Authors
M. V. Khutornaya
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Ac. L.S. Barbarasha blvd, Kemerovo, 650002
A. V. Ponasenko
Moscow Scientific and Practical Center for Narcology
Russian Federation
Russian Federation
37/1, Lyublinskaya st., Moscow, 109390
A. V. Sinitskaya
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Ac. L.S. Barbarasha blvd, Kemerovo, 650002
O. N. Hryachkova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Ac. L.S. Barbarasha blvd, Kemerovo, 650002
A. O. Poddubnyak
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Ac. L.S. Barbarasha blvd, Kemerovo, 650002
M. Yu. Sinitsky
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Ac. L.S. Barbarasha blvd, Kemerovo, 650002
References
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Review
For citations:
Khutornaya M.V., Ponasenko A.V., Sinitskaya A.V., Hryachkova O.N., Poddubnyak A.O., Sinitsky M.Yu. Polymorphism of genes involved in vitamin D metabolism and inflammatory response in patients with coronary artery disease. Medical Genetics. 2025;24(7):116-118. (In Russ.) https://doi.org/10.25557/2073-7998.2025.07.116-118
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