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Angiogenesis inhibitor genes expression of the Wistar rat heart exposure to low-dose doxorubicin
https://doi.org/10.25557/2073-7998.2025.07
Abstract
Angiogenesis plays an important role in the metabolism of cardiomycotes, affecting their functioning and vital activity, as well as the process of cellular aging. The aim of the study was to determine the expression level of angiogenesis inhibitor genes in the heart of Wistar rats under low-dose exposure to doxorubicin. The study included two groups of 10 male Wistar rats, the expression of angiogenesis genes was determined using qPCR. The experimental group was characterized by increased expression of the Il1rn and Rnh1 genes. Low-dose subacute exposure to doxorubicin indirectly activates the expression of angiogenesis inhibitor genes, which aggravates the cardiotoxic effects of the toxin.
About the Authors
M. A. Asanov
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Academician Barbarash boulevard, Kemerovo, 650002
A. O. Poddubnyak
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Academician Barbarash boulevard, Kemerovo, 650002
A. V. Sinitskaya
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Academician Barbarash boulevard, Kemerovo, 650002
M. Yu. Sinitsky
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
6, Academician Barbarash boulevard, Kemerovo, 650002
References
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Review
For citations:
Asanov M.A., Poddubnyak A.O., Sinitskaya A.V., Sinitsky M.Yu. Angiogenesis inhibitor genes expression of the Wistar rat heart exposure to low-dose doxorubicin. Medical Genetics. 2025;24(7):24-25. (In Russ.) https://doi.org/10.25557/2073-7998.2025.07
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