Association of single nucleotide polymorphism rs2900262 of the C9orf16 with severe course of COVID-19

Abstract

Proteins with chaperone activity, including the recently discovered class of Hero proteins, are involved in the pathogenesis of viral infections, the development of the immune response, and the maintenance of homeostasis. To study the association of the rs2900262 polymorphism of the C9orf16, encoding a protein belonging to the Hero class, we performed genotyping of single nucleotide polymorphism in 898 unrelated individuals from Central Russia, including 199 patients with severe COVID-19. It was found that the T allele of rs2900262 C9orf16 correlates with a decrease in activated partial thromboplastin time (APTT) in males, indicating the prevalence of thrombus formation processes. It was also found that this polymorphism is associated with fewer days on O2 and a decrease in the C-reactive protein (CRP) count in the group with low fruit and vegetable intake.