Generate QR code
Open Access
Subscription Access
Genetic polymorphisms of APEX1 rs1130409, hOGG1 rs1052133,XRCC1 rs25489, XРD rs13181 and its association with breast cancer in women younger than 55 years
https://doi.org/10.25557/2073-7998.2025.05.56-58
Abstract
The associations of gene polymorphism (APEX1 rs1130409, hOGG1 rs1052133, XRCC1 rs25489, XPD rs13181) were studied in 210 women living in the Kemerovo region diagnosed with breast cancer and 224 healthy women from Kuzbass, who formed a comparison group. Associations of breast cancer with the APEX1 rs1130409 for the log-additive inheritance model (OR=0.74; 95% CI=0.57–0.97; p=0.03) and hOGG1 (rs1052133) for the dominant inheritance model (OR=1.54; 95% CI=1.05–2.27; p=0.02) were revealed.
Supporting agencies: The work was carried out under a state assignment (Project No. 124041100077-1 «Immunohormonal interactions in breast cancer», 2024– 2025 or FWEZ-2024-0012).
About the Authors
M. L. Bakanova
The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, (FRC CCC SB RAS);
Kemerovo State Medical University
Russian Federation
Russian Federation
18, Sovietskiy st., Kemerovo, 650065, Russian Federation
22a Voroshilova st., Kemerovo, 650056, Russian Federation
V. I. Minina
The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, (FRC CCC SB RAS);
Кеmerovo State University (KemSU)
Russian Federation
Russian Federation
18, Sovietskiy st., Kemerovo, 650065, Russian Federation
6, Krasnaya st., Kemerovo, 650000, Russian Federation
Ya. A. Zakharova
The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, (FRC CCC SB RAS);
Кеmerovo State University (KemSU)
Russian Federation
Russian Federation
18, Sovietskiy st., Kemerovo, 650065, Russian Federation
6, Krasnaya st., Kemerovo, 650000, Russian Federation
References
1. Siegel R.L., Miller K.D., Fuchs H.E., Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021;71(1):7-33. doi: 10.3322/caac.21654. Erratum in: CA Cancer J Clin. 2021;71(4):359. doi: 10.3322/caac.21669.
2. Sanjari Moghaddam A., Nazarzadeh M., Bidel Z., et al. hOGG1 gene polymorphism and breast cancer risk: A systematic review and meta-analysis study. Breast J. 2018;24(1):70-73. doi: 10.1111/tbj.12842.
3. Kim K.Y.., Han W, Noh D.Y., Kang D., Kwack K. Impact of genetic polymorphisms in base excision repair genes on the risk of breast cancer in a Korean population. Gene. 2013;532(2):192-6. doi: 10.1016/j.gene.2013.09.069.
4. Wang T., Wang H., Yang S.et al. Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China. BMC Med Genet. 2018;19(1):67. doi: 10.1186/s12881-018-0578-9.
Review
For citations:
Bakanova M.L., Minina V.I., Zakharova Ya.A. Genetic polymorphisms of APEX1 rs1130409, hOGG1 rs1052133,XRCC1 rs25489, XРD rs13181 and its association with breast cancer in women younger than 55 years. Medical Genetics. 2025;24(5):56-58. (In Russ.) https://doi.org/10.25557/2073-7998.2025.05.56-58
Views:
12
Email this article 