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Transcriptome analysis in the study of genetic diversity of human populations in health and pathology
https://doi.org/10.25557/2073-7998.2025.05.52-53
Abstract
Preeclampsia (PE) is a severe disorder with varying incidence and severity across modern human populations. Defects in the maturation of placental decidual cells (DC) are known to contribute to endothelial dysfunction and the development of PE. In this study the analysis focused on identifying commonalities and specificities in DC expression profiles across populations in normal pregnancy and PE, as well as assessing the impact of interpopulation differences on overall gene expression variability.
Supporting agencies: The work was carried out within the framework of the state assignment (№ 122020200083-8).
About the Authors
A. A. Babovskaya
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
E. A. Trifonova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
A. A. Zarubin
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
L. V. Rychkova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
16, Timiryazeva st., Irkutsk, 664003, Russian Federation
V. A. Stepanova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
References
1. Ghosh G., Grewal J., Männistö T. et al. Racial/ethnic differences in pregnancy-related hypertensive disease in nulliparous women. Ethn Dis. 2014; 24(3):283-9.
2. Conrad K., Rabaglino M., Post Uiterweer ED. Emerging role for dysregulated decidualization in the genesis of preeclampsia. Placenta. 2017; 60:119-129.
3. Babovskaya A.A., Trifonova E.A., Serebrova V.N. et al. Protocol of transcriptome analysis of decidual placenta cells. Molecular biology. 2022; 56(2): 276-282. (In Russ.). DOI: 10.1134/S0026893322020030.
Review
For citations:
Babovskaya A.A., Trifonova E.A., Zarubin A.A., Rychkova L.V., Stepanova V.A. Transcriptome analysis in the study of genetic diversity of human populations in health and pathology. Medical Genetics. 2025;24(5):52-53. (In Russ.) https://doi.org/10.25557/2073-7998.2025.05.52-53
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