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Loci associated with arterial hypertension as genetic markers of peripheral artery disease

https://doi.org/10.25557/2073-7998.2025.04.65-67

Abstract

The aim of this study was to investigate the relationship between five polymorphisms identified by genome-wide association studies as susceptibility loci for arterial hypertension and the risk of developing peripheral artery disease (PAD). The rs7129220 locus in the AMPD3 gene was found to be associated with an increased risk of PAD (OR = 7.584; 95% CI: 1.89-30.33; Pperm=0.0001), regardless of gender. The polymorphism rs4373814 in the CACNB2 gene exhibited a statistically significant negative correlation with the ankle-brachial index (β=-0.053; Pperm=0.03). Additionally, SNP rs932764 in the PLCE1 gene was associated with elevated levels of low-density lipoprotein cholesterol (β=0.211; Pperm=0.03) and triglycerides (β=0.048; Pperm=0.04) in the plasma of patients with PAD. These findings suggest potential pleiotropic effects of genes involved in blood pressure regulation on other phenotypes related to atherosclerosis.

About the Authors

S. N. Zhabin
Kursk State Medical University
Russian Federation

3, K. Marx st, Russia, Kursk, 305041



V. A. Lazarenko
Kursk State Medical University
Russian Federation

3, K. Marx st, Russia, Kursk, 305041



Iu. E. Azarova
Kursk State Medical University
Russian Federation

3, K. Marx st, Russia, Kursk, 305041



M. A. Solodilova
Kursk State Medical University
Russian Federation

3, K. Marx st, Russia, Kursk, 305041



A. V. Polonikov
Kursk State Medical University
Russian Federation

3, K. Marx st, Russia, Kursk, 305041



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Review

For citations:


Zhabin S.N., Lazarenko V.A., Azarova I.E., Solodilova M.A., Polonikov A.V. Loci associated with arterial hypertension as genetic markers of peripheral artery disease. Medical Genetics. 2025;24(4):65-67. (In Russ.) https://doi.org/10.25557/2073-7998.2025.04.65-67

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ISSN 2073-7998 (Print)