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Epidemiological aspects of obesity-associated polymorphisms among children and adolescents in Yakutia
https://doi.org/10.25557/2073-7998.2025.04.37-39
Abstract
The increasing incidence of obesity among the younger generation is one of the key problems of modern society, while the genetic factor is considered as a likely prerequisite for the development of this disease. Analysis of polymorphic variants of the PPARG, FABP2, ADRB2, and ADRB3 genes in 258 respondents showed a predominance of the frequency of the rs1042713 risk allele of the ADRB2 gene in the study sample, which may indicate its possible association with the development of obesity among children and adolescents.
Keywords
Supporting agencies: The work was carried out within the framework of the State Assignment of the Ministry of Science and Higher Education (projects WRS-2025-0028,FSRG-2024-0001)
About the Authors
D. A. Vasileva
Yakut Scientific Center of the Siberian Branch of the Russian Academy of Sciences;
North-Eastern Federal University
Russian Federation
Russian Federation
2, Petrovskogo st., Yakutsk, 677008,
58, Belinskogo st., Yakutsk, 677000
A. I. Fedorov
Yakut Scientific Center of the Siberian Branch of the Russian Academy of Sciences;
North-Eastern Federal University
Russian Federation
Russian Federation
2, Petrovskogo st., Yakutsk, 677008,
58, Belinskogo st., Yakutsk, 677000
U. M. Lebedeva
North-Eastern Federal University
Russian Federation
Russian Federation
58, Belinskogo st., Yakutsk, 677000
L. R. Zhozhikov
Yakut Scientific Center of the Siberian Branch of the Russian Academy of Sciences;
North-Eastern Federal University
Russian Federation
Russian Federation
2, Petrovskogo st., Yakutsk, 677008,
58, Belinskogo st., Yakutsk, 677000
A. M. Lebedeva
Yakut Scientific Center of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
2, Petrovskogo st., Yakutsk, 677008
N. R. Maximova
Yakut Scientific Center of the Siberian Branch of the Russian Academy of Sciences;
North-Eastern Federal University
Russian Federation
Russian Federation
2, Petrovskogo st., Yakutsk, 677008,
58, Belinskogo st., Yakutsk, 677000
References
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2. Dallongeville J., Helbecque N., Cottel D., et al. The Gly16-->Arg16 and Gln27-->Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men. J Clin Endocrinol Metab. 2003;88(10):4862-6. doi: 10.1210/jc.2003-030173.
3. Daghestani M.H., Omair M., Daghestani M. et al. Influence of b2 adrenergic receptor polymorphism (rs1042713 and rs1042714) on anthropometric, hormonal and lipid profiles in polycystic ovarian syndrome. J Med Biochem. 2021;40(1):74-85. doi: 10.5937/jomb0-26183.
Review
For citations:
Vasileva D.A., Fedorov A.I., Lebedeva U.M., Zhozhikov L.R., Lebedeva A.M., Maximova N.R. Epidemiological aspects of obesity-associated polymorphisms among children and adolescents in Yakutia. Medical Genetics. 2025;24(4):37-39. (In Russ.) https://doi.org/10.25557/2073-7998.2025.04.37-39
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