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FTO (rs9939609), FABP2 (rs1799883), and PPARG (rs1801282) gene polymorphisms and obesity risk in men living in Kuzbass
https://doi.org/10.25557/2073-7998.2022.09.13-16
Abstract
Purpose: To investigate the associations of FTO, FABP2, PPARG gene polymorphism and body mass index in Kuzbass residents. Methods. The sample for the study was 395 men, residents of Kuzbass. The average age of the subjects was 59±7.7 years. According to the questionnaire data, all the examined men referred themselves to the Russian nationality. The frequency of obesity in this sample (body mass index>30) was 46.3%. Genotyping of 3 polymorphic variants: FTO (rs9939609), FABP2 (rs1799883), and PPARG (rs1801282) were performed using TaqMan PCR. The association of these polymorphic variants with obesity in various inheritance models was then tested. Results. The associations of FTO rs9939609 gene variants with obesity in the codominant (for genotype T/A OR = 2.05; CI: 1.26-3.33; p = 0.004; for genotype A/A (OR = 2.27; CI: 1.28-4.04; p = 0.004) and dominant inheritance models (OR = 2.12; CI: 1.34-3.34 p = 0.001) were detected. Other genes showed no significant association with obesity in our sample. Conclusion. The rs9939609 variant of the FTO gene is associated with an increased risk of obesity in Kuzbass residents.
About the Authors
A. A. Yakovleva
Kemerovo State University
Russian Federation
Russian Federation
A. V. Torgunakova
Kemerovo State University
Russian Federation
Russian Federation
O. A. Soboleva
Kemerovo State University
Russian Federation
Russian Federation
V. I. Minina
Kemerovo State University
Russian Federation
Russian Federation
References
1. Дедов И.И., Мокрышева Н.Г., Мельниченко Г.А. и др. Ожирение. Consilium Medicum. 2021;23 (4):311-325.
2. Дедов И.И., Мельниченко Г.А., Шестакова М.В.,и др. Национальные клинические рекомендации по лечению морбидного ожирения у взрослых. 3-ий пересмотр (лечение морбидного ожирения у взрослых). Ожирение и метаболизм. 2018;15(1):53-70. https://doi.org/10.14341/omet2018153-70
3. Барбараш О.Л., Каретникова В.Н., Кочергина А.М. и др. Избыточная масса тела и ожирение среди жителей Кемеровской области: распространенность, ассоциация с факторами сердечно-сосудистого риска. Кардиология: Новости. Мнения. Обучение. 2016;4(11):44-49.
4. Егоренкова Н.П., Сорокина Е.Ю., Погожева А.В. и др. Изучение особенностей метаболизма у лиц с полиморфизмом rs9939609 гена FTO. Вопросы питания. 2015;84(4):97-104.
5. Qiu C.J., Ye X.Z., Yu X.J. et al. Association between FABP2 Ala54Thr polymorphisms and type 2 diabetes mellitus risk: a HuGE Review and Meta-Analysis. J Cell Mol Med. 2014;18(12):2530-2535.
6. Muñoz-Yáñez C., Pérez-Morales R., Moreno-Macías H., et al. Polymorphisms FTO rs9939609, PPARG rs1801282 and ADIPOQ rs4632532 and rs182052 but not lifestyle are associated with obesity related-traits in Mexican children. Genet Mol Biol. 2016;39(4):547-553.
7. Бондарева Э.А., Задорожная Л.В., Хомякова И.А. Т/А-полиморфизм гена FTO и образ жизни ассоциированы с накоплением жира в разных возрастных группах мужчин. Ожирение и метаболизм. 2019;16(2):49-53.
8. Батурин А.К., Сорокина Е.Ю., Погожева А.В. и др. Региональные особенности полиморфизма генов, ассоциированных с ожирением (rs9939609 гена FTO и Trp64Arg гена ADRB3), у населения России. Вопросы питания. 2014;83(2):35-41.
9. Prakash J., Mittal B., Srivastava A. et al. Association of FTO rs9939609 SNP with Obesity and Obesity- Associated Phenotypes in a North Indian Population. Oman Med J. 2016;31(2):99-106.
10. Quan L.L., Wang H., Tian Y. et al. Association of fat-mass and obesity-associated gene FTO rs9939609 polymorphism with the risk of obesity among children and adolescents: a meta-analysis. Eur Rev Med Pharmacol Sci. 2015;19(4):614-623.
11. Vimaleswaran K.S., Radha V., Mohan V. Thr54 allele carriers of the Ala54Thr variant of FABP2 gene have associations with metabolic syndrome and hypertriglyceridemia in urban South Indians. Metabolism. 2006;55(9):1222-1226.
12. Maculewicz E., Leońska-Duniec A., Mastalerz A., Szarska E., Garbacz A., Lepionka T., Łakomy R., Anyżewska A., Bertrandt J. The Influence of FTO, FABP2, LEP, LEPR, and MC4R Genes on Obesity Parameters in Physically Active Caucasian Men.Int J Environ Res Public Health. 2022;19(10):1-11.
13. Muñoz-Yáñez C., Pérez-Morales R., Moreno-Macías H. et al. Polymorphisms FTO rs9939609, PPARG rs1801282 and ADIPOQ rs4632532 and rs182052 but not lifestyle are associated with obesity related-traits in Mexican children. Genet Mol Biol. 2016;39(4):547-553.
Review
For citations:
Yakovleva A.A., Torgunakova A.V., Soboleva O.A., Minina V.I. FTO (rs9939609), FABP2 (rs1799883), and PPARG (rs1801282) gene polymorphisms and obesity risk in men living in Kuzbass. Medical Genetics. 2022;21(9):13-16. (In Russ.) https://doi.org/10.25557/2073-7998.2022.09.13-16
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