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Analysis of polymorphism of the MMP1 gene in miners of the Kemerovo region
https://doi.org/10.25557/2073-7998.2022.08.58-60
Abstract
The study involved 559 miners living in the Kemerovo region of Russia were examined, including 236 patients with lung cancer and 323 without signs of oncological diseases. A comparative analysis of polymorphic variants of the MMP1 -1607insG (rs1799750) gene was carried out in miners with lung cancer and individuals without cancer living in the same area. Analysis of single-locus effects showed a significant relationship between the risk of lung cancer and the 2G/2G genotype of the MMP1 gene in the general group (OR = 1.55, CI: 1.08-2.21, p = 0.02) and the smoking group (OR= 2.08 95% CI: 2.08 1.20- 3.59, p=0.008). The 2G allele also showed a significant association with the risk of developing PD in miners in the general group (OR= 1.32 95% CI: 1.04-1.67, p=0.02) and the smoking group (OR= 1.63 95% CI: 1.16-2.31, p =0.005).
About the Authors
R. A. Titov
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS; Kemerovo State University
Russian Federation
Russian Federation
V. I. Minina
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS; Kemerovo State University
Russian Federation
Russian Federation
A. V. Torgunakova
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS; Kemerovo State University
Russian Federation
Russian Federation
A. V. Marushchak
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS
Russian Federation
Russian Federation
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Review
For citations:
Titov R.A., Minina V.I., Torgunakova A.V., Marushchak A.V. Analysis of polymorphism of the MMP1 gene in miners of the Kemerovo region. Medical Genetics. 2022;21(8):58-60. (In Russ.) https://doi.org/10.25557/2073-7998.2022.08.58-60
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