Generate QR code
Open Access
Subscription Access
Analysis of polymorphism of the MMP1 gene in miners of the Kemerovo region
https://doi.org/10.25557/2073-7998.2022.08.58-60
Abstract
The study involved 559 miners living in the Kemerovo region of Russia were examined, including 236 patients with lung cancer and 323 without signs of oncological diseases. A comparative analysis of polymorphic variants of the MMP1 -1607insG (rs1799750) gene was carried out in miners with lung cancer and individuals without cancer living in the same area. Analysis of single-locus effects showed a significant relationship between the risk of lung cancer and the 2G/2G genotype of the MMP1 gene in the general group (OR = 1.55, CI: 1.08-2.21, p = 0.02) and the smoking group (OR= 2.08 95% CI: 2.08 1.20- 3.59, p=0.008). The 2G allele also showed a significant association with the risk of developing PD in miners in the general group (OR= 1.32 95% CI: 1.04-1.67, p=0.02) and the smoking group (OR= 1.63 95% CI: 1.16-2.31, p =0.005).
About the Authors
R. A. Titov
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS; Kemerovo State University
Russian Federation
Russian Federation
V. I. Minina
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS; Kemerovo State University
Russian Federation
Russian Federation
A. V. Torgunakova
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS; Kemerovo State University
Russian Federation
Russian Federation
A. V. Marushchak
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS
Russian Federation
Russian Federation
References
1. Cassidy A., Duffy S.W., Myles J.P. et al. Lung cancer risk prediction: a tool for early detection.Int J. Cancer. 2007; 120:1-6.
2. Арутюнян А.Ф., Гайдуков С.Н., Костюшов В.Е. Генетические и допплерометрические аспекты профилактики рецидивов миомы матки, сочетанной с аденомиозом после миомэктомии. Медицинские науки. 2015;4: 26-35.
3. Liao C.H., Tsai C.W., Chang W.S., et al. Association of Matrix Metalloproteinase-1 Genotypes With Bladder Cancer Risk. In Vivo. 2021 Sep-Oct;35(5):2535-2540. doi: 10.21873/invivo.12535.
4. Rutter J.L., Mitchell T.I., Butticè G., et al. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription. Cancer Res. 1998 Dec 1;58(23):5321-5.
5. Tower G.B., Coon C.I., Brinckerhoff C.E. The 2G single nucleotide polymorphism (SNP) in the MMP-1 promoter contributes to high levels of MMP-1 transcription in MCF-7/ADR breast cancer cells. Breast Cancer Res Treat. 2003 Nov;82(2):75-82. doi: 10.1023/B:BREA.0000003948.14026.7c.
6. Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning. A Laboratory Manual. N.Y.: Cold Spring Harbor Lab. 1989. P.1659
7. Liu D., Guo H., Li Y., Xu X., Yang K., Bai Y. Association between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysis. PLoS One. 2012;7(2):e31251. doi: 10.1371/journal.pone.0031251.
Review
For citations:
Titov R.A., Minina V.I., Torgunakova A.V., Marushchak A.V. Analysis of polymorphism of the MMP1 gene in miners of the Kemerovo region. Medical Genetics. 2022;21(8):58-60. (In Russ.) https://doi.org/10.25557/2073-7998.2022.08.58-60
Views:
298
Email this article 