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The effect of genes regulating glutamatergic and GABAergic neurotransmission in working memory
https://doi.org/10.25557/2073-7998.2022.07.46-49
Abstract
The aim of our study was to assess the involvement of polymorphic variants of genes responsible for the regulation of glutamatergic and GABAergic neurotransmission in the formation of differences in the volume of working memory in 1011 university students of the Republic of Bashkortostan and the Republic of Udmurtia. As a result of linear regression analysis, the association of the polymorphic locus rs4971648 of the NRXN1 gene was shown (p = 0.008; β = - 0.84) with variations in the amount of working memory in smoking individuals.The obtained data contribute to the understanding of the molecular genetic mechanisms underlying individual differences in the amount of working memory.
About the Authors
R. F. Enikeeva
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Bashkir State University
Russian Federation
Russian Federation
A. V. Kazantseva
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Bashkir State University
Russian Federation
Russian Federation
Yu. D. Davydova
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Bashkir State University
Russian Federation
Russian Federation
R. N. Mustafin
Bashkir State University; Bashkir State Medical University
Russian Federation
Russian Federation
M. M. Lobaskova
Psychological Institute, Russian Academy of Education
Russian Federation
Russian Federation
S. B. Malykh
Psychological Institute, Russian Academy of Education
Russian Federation
Russian Federation
E. K. Khusnutdinova
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Bashkir State University
Russian Federation
Russian Federation
References
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Review
For citations:
Enikeeva R.F., Kazantseva A.V., Davydova Yu.D., Mustafin R.N., Lobaskova M.M., Malykh S.B., Khusnutdinova E.K. The effect of genes regulating glutamatergic and GABAergic neurotransmission in working memory. Medical Genetics. 2022;21(7):46-49. (In Russ.) https://doi.org/10.25557/2073-7998.2022.07.46-49
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