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The effect of DNA methylation and genetic variants of the hypothalamic-pituitary-adrenal system with phenotypic variations in depression
https://doi.org/10.25557/2073-7998.2022.07.40-42
Abstract
The present study aimed to assess the effect of DNA methylation and genetic variants of the hypothalamic-pituitary-adrenal system with phenotypic variance in depression in 1065 mentally healthy individuals controlling for sex and ethnicity. As a result of linear regression analysis, the association of polymorphic loci rs53576, rs7632287 and rs2254298 of the OXTR gene, rs1042615 and rs3803107 of the AVPR1A gene, as well as rs28632197 of the AVPR1B gene with depression level was revealed. In addition, the association of the methylation status of the OXT (Р=0,003; OR=2,12) and AVPR1A (Р=0,013; OR=3,38) genes and an increased risk of developing depression was found. The results contribute to understanding the biological basis of depression and identifying biomarkers of depressive behavior.
About the Authors
Yu. D. Davydova
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Bashkir State University
Russian Federation
Russian Federation
A. V. Kazantseva
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Bashkir State University; Ufa State Petroleum Technological University
Russian Federation
Russian Federation
R. F. Enikeeva
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Bashkir State University
Russian Federation
Russian Federation
R. N. Mustafin
Bashkir State University; Bashkir State Medical University
Russian Federation
Russian Federation
M. M. Lobaskova
Psychological Institute, Russian Academy of Education
Russian Federation
Russian Federation
S. B. Malykh
Psychological Institute, Russian Academy of Education
Russian Federation
Russian Federation
E. K. Khusnutdinova
Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Bashkir State University
Russian Federation
Russian Federation
References
1. Broniarczyk-Czarniak M., Szemraj J., Smigielski J., Galecki P. The Role of OXT, OXTR, AVP, and AVPR1a Gene Expression in the Course of Schizophrenia. Curr Issues Mol Biol. 2022;44(1):336-349. doi: 10.3390/cimb44010025
2. Kazantseva A., Davydova Yu., Enikeeva R. et al. AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level. Heliyon. 2020;6(10):e05240. doi: 10.1016/j.heliyon.2020.e05240
3. De Carvalho L.M., Chen W.-Y., Lasek A.W. Epigenetic mechanisms underlying stress-induced depression.Int Rev Neurobiol. 2021;156:87-126. doi: 10.1016/bs.irn.2020.08.001
Review
For citations:
Davydova Yu.D., Kazantseva A.V., Enikeeva R.F., Mustafin R.N., Lobaskova M.M., Malykh S.B., Khusnutdinova E.K. The effect of DNA methylation and genetic variants of the hypothalamic-pituitary-adrenal system with phenotypic variations in depression. Medical Genetics. 2022;21(7):40-42. (In Russ.) https://doi.org/10.25557/2073-7998.2022.07.40-42
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