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Antimutagenic activity and hepatoprotective effect of anti-radiation drugs

Abstract

The antimutagenic activity of anti-radiation drugs betaleukin, flagellin, indraline and riboxin with different mechanisms of action was studied in short-term and chronic experiments in mice in vivo. All drugs showed antimutagenic properties in bone marrow cells, as well as hepatoprotective effect. The greatest effect under the used experimental conditions was noted for betaleukin and the new anti-radiation drug flagellin.

About the Authors

L. P. Sycheva
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Russian Federation


L. M. Rozhdestvenskii
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Russian Federation


N. I. Lisina
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Russian Federation


T. G. Shliakova
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Russian Federation


V. V. Zorin
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Russian Federation


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For citations:


Sycheva L.P., Rozhdestvenskii L.M., Lisina N.I., Shliakova T.G., Zorin V.V. Antimutagenic activity and hepatoprotective effect of anti-radiation drugs. Medical Genetics. 2020;19(9):81-82. (In Russ.)

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ISSN 2073-7998 (Print)