Deuterium oxide enhances the SOS response of Escherichia coli induced by bactericidal agents
Abstract
We studied the genotoxic effect of bactericidal agents: dioxine, furaciline and nalidixic acid on cells of the deuterated culture lux-biosensor E. coli MG1655 (pColD::lux), which luminesces as a result of activation of the colicin gene promoter colD in response to DNA damage. For the first time, it was shown that deuterium oxide (D2O) at a concentration of 9% increases the SOS response by 1.6-2.8 times in E. coli cells induced by the studied drugs.
About the Authors
S. V. Smirnova
Vavilov Institute of General Genetics of Russian Academic Science
Russian Federation
T. N. Shapiro
Vavilov Institute of General Genetics of Russian Academic Science
Russian Federation
E. V. Igonina
Vavilov Institute of General Genetics of Russian Academic Science
Russian Federation
S. K. Abilev
Vavilov Institute of General Genetics of Russian Academic Science
Russian Federation
For citations:
Smirnova S.V.,
Shapiro T.N.,
Igonina E.V.,
Abilev S.K.
Deuterium oxide enhances the SOS response of Escherichia coli induced by bactericidal agents. Medical Genetics. 2020;19(9):79-80.
(In Russ.)
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