Assessment of genotoxic effects in one-and two-cell mouse embryos in vivo and in vitro using comet assay

Abstract

A methodology for evaluating DNA damage in one - and two-cell mouse embryos using the comet assay has been developed. The applicability of the developed methodology for assessing genotoxicity in vivo and in vitro was confirmed in experiments with model genotoxicants - methyl methanesulfonate, dioxidine, etoposide and mitomycin C.