Distribution by sex and age of patients with monogenic pathology and gender and age structure of urban and rural populations of North Ossetia

The influence of population-genetic structure on the prevalence of monogenic and multifactorial pathology is no longer in doubt. The purpose of this study is to study the gender and age structure of the population of North Ossetia-Alania in the framework of a comprehensive genetic and epidemiological survey of the population and comparison with the obtained data of distribution of gender and age characteristics of patients with hereditary pathology. On the basis of statistical data as of January 1, 2018, the gender and age structure of North Ossetia population is analyzed by a standard method, 1054 patients with confirmed diagnosis and type of inheritance were identified in 4 districts: Ardonsky, Alagirsky, Pravoberezhny, Kirovsky. Gender and age pyramids for the urban and rural population of North Ossetia, having the form of a bell, between which no significant differences were revealed, were compiled. There has been a slight increase in fertility in the urban population, due to the outflow of young people to the cities from rural areas. The reproductive part does not exceed a quarter of the population. There is a predominance of women in older age groups. The ratio of males to females is 1:1.19 in the urban population, 1:1.11 in the rural population, the ratio is different in different age cohorts. Aging rate 17.2%. The demographic burden ratio is 39.4%. The proportion of children and older persons is almost the same. It is shown that the gender-age structure of North Ossetia is characterized by a stationary type and an old population with a practically simple reproduction character. Among patients with hereditary pathology, other characteristics of the gender and age structure are observed. in all age cohorts, the number of men exceeds the number of women.

gender and age structure, North Ossetia, genetic epidemiology