A study of the expression of circular RNAs of the Ece1, Mvp, Egfem1, Cdyl and Rgs9 genes in transient cerebral ischemia model conditions

L. V. Valieva; I. B. Filippenkov; V. V. Stavchansky; A. E. Denisova; L. V. Gubsky; S. A. Limborska; L. V. Dergunova

doi:10.25557/2073-7998.2020.05.69-70

A study of the expression of circular RNAs of the Ece1, Mvp, Egfem1, Cdyl and Rgs9 genes in transient cerebral ischemia model conditions

L. V. Valieva, I. B. Filippenkov, V. V. Stavchansky, A. E. Denisova, L. V. Gubsky, S. A. Limborska, L. V. Dergunova

https://doi.org/10.25557/2073-7998.2020.05.69-70

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Abstract

Using real-time PCR, the activating effect of ischemia on the expression of circular RNAs (circRNAs) of Ece1, Mvp, Egfem1 and Cdyl genes, as well as the repressing effect on the expression of circRNA of the Rgs9 gene, is shown in the subcortical structures of the rat brain containing the focus of ischemic damage. Bioinformatics analysis revealed possible cis-regulatory interactions between miRNAs, as well as circRNAs and mRNAs of the studied genes. The result indicates the functional role of these circRNAs in the response of brain cells to ischemia.