Genetic predictors of early coronary in-stent restenosis

Abstract

Currently, restenosis is a major challenge arising after percutaneous coronary interventions. Causes of re-narrowing of the artery after stenting include clinical, angiographic, and genetic factors. Some polymorphic loci of the renin-angiotensin-aldosterone system, folate cycle, and endothelial nitric oxide synthase genes have been studied. Genetic variants associated with the restenosis developing at different time periods after stent implantation (within the first 6 months or later) have been identified.