Features of CpG site methylation within miRNA gene MIR10B and transcription factor gene TWIST1 in atherosclerosis
https://doi.org/10.25557/2073-7998.2020.05.44-45
Abstract
We analyzed DNA methylation profiles within genes of miR-10b and TWIST1 regulating the expression of this microRNA in blood vessels and blood leukocytes of patients with advanced atherosclerosis and in relatively healthy individuals. MIR10B hypomethylation was detected in arteries affected by atherosclerosis in comparison with unaffected arteries and veins. Methylation profile of TWIST1 gene was tissue-specific and consistent regardless of atherosclerosis.
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About the Authors
A. V. Markov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
N. P. Babushkina
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
M. V. Golubenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
R. R. Salakhov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. A. Zarubin
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. A. Sleptsov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
Yu. A. Koroleva
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
D. V. Sharysh
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
E. F. Muslimova
Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
S. A. Afanasyev
Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
M. S. Kuznetsov
Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
B. N. Kozlov
Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
M. S. Nazarenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
Review
For citations:
Markov A.V., Babushkina N.P., Golubenko M.V., Salakhov R.R., Zarubin A.A., Sleptsov A.A., Koroleva Yu.A., Sharysh D.V., Muslimova E.F., Afanasyev S.A., Kuznetsov M.S., Kozlov B.N., Nazarenko M.S. Features of CpG site methylation within miRNA gene MIR10B and transcription factor gene TWIST1 in atherosclerosis. Medical Genetics. 2020;19(5):44-45. (In Russ.) https://doi.org/10.25557/2073-7998.2020.05.44-45
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