Analysis of histaminergic system genes expression level in the early symptom stage of Parkinson’s disease

E. I. Semyonova; M. M. Rudenok; I. N. Rybolovlev; P. A. Slominsky; M. I. Shadrina

doi:10.25557/2073-7998.2020.04.105-106

Analysis of histaminergic system genes expression level in the early symptom stage of Parkinson’s disease

E. I. Semyonova, M. M. Rudenok, I. N. Rybolovlev, P. A. Slominsky, M. I. Shadrina

https://doi.org/10.25557/2073-7998.2020.04.105-106

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Abstract

The goal of this work was to study changes of histaminergic system genes expression level in the early symptom stage of PD. We were use MPTP mouse model of early symptom stage of PD in this study. Male mice C57BL/6 were used (n=10 in the control and experimental groups). For analysis we were choose nine genes, which associated with histaminergic system. Measuring of expression levels was carried out using reverse transcription reaction and real-time PCR (TaqMan). Changes at the mRNA level for a number of genes in the brain tissues of mice with MPTP-induced PD were founded. Based on these data, it can be suggested that histaminergic system is involve in early stage PD pathogenesis.