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Transcriptome analysis of dermal fibroblasts, derived from Parkinson’s disease discordant twins
https://doi.org/10.25557/2073-7998.2020.04.92-93
Abstract
Analysis of transcriptome of fibroblasts, derived from twins, discordant in sporadic form of PD, have been conducted for the first time. We have obtained the evidence for potential utility of fibroblast studies for undrestanding the processes, underlying the PD pathogenesis. Also, our data highlights 3 possible candidate PD genes - GRIK2, PTGS2 & SCN9A.
About the Authors
I. N. Vlasov
Institute of Molecular Genetics of Russian Academy of Scieces
Russian Federation
Russian Federation
E. V. Novosadova
Institute of Molecular Genetics of Russian Academy of Scieces
Russian Federation
Russian Federation
M. M. Rudenok
Institute of Molecular Genetics of Russian Academy of Scieces
Russian Federation
Russian Federation
E. V. Arsenieva
Institute of Molecular Genetics of Russian Academy of Scieces
Russian Federation
Russian Federation
A. V. Rosinskaya
Institute of Molecular Genetics of Russian Academy of Scieces
Russian Federation
Russian Federation
I. A. Grivennikov
Institute of Molecular Genetics of Russian Academy of Scieces
Russian Federation
Russian Federation
P. A. Slominskiy
Institute of Molecular Genetics of Russian Academy of Scieces
Russian Federation
Russian Federation
M. I. Shadrina
Institute of Molecular Genetics of Russian Academy of Scieces
Russian Federation
Russian Federation
A. K. Alieva
Institute of Molecular Genetics of Russian Academy of Scieces
Russian Federation
Russian Federation
Review
For citations:
Vlasov I.N., Novosadova E.V., Rudenok M.M., Arsenieva E.V., Rosinskaya A.V., Grivennikov I.A., Slominskiy P.A., Shadrina M.I., Alieva A.K. Transcriptome analysis of dermal fibroblasts, derived from Parkinson’s disease discordant twins. Medical Genetics. 2020;19(4):92-93. (In Russ.) https://doi.org/10.25557/2073-7998.2020.04.92-93
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