The role of presynaptic cytomatrix protein Piccolo and inflammatory genes in the development of depressive behavior

Abstract

The present study aimed to assess the main effects of IL1B (rs16944), TNF (rs1041981), CRP (rs3093077) and PCLO (rs2715157) gene polymorphisms together with G×E effects on individual differences in depression level in 999 mentally healthy individuals with sex and ethnicity as covariates. Statistical analysis revealed an association of TNF rs1041981 A-allele with a decreased depression level in Russians (p=0.04), while PCLO rs2715157 A-allele was associated with an increased depression level in Tatars (pFDR=0.03). As a result of stratification analysis we observed that place of residence and birth season significantly affected association of rs16944, rs1041981 and rs2715157 and depression level.