Influence of genotype and environment on DNA methylation within shared index loci of schizophrenia and intelligence

M. V. Alfimova; N. V. Kondratyev; M. I. Bolgov; M. V. Gabaeva; V. E. Golimbet

doi:10.25557/2073-7998.2020.04.10-11

Influence of genotype and environment on DNA methylation within shared index loci of schizophrenia and intelligence

M. V. Alfimova, N. V. Kondratyev, M. I. Bolgov, M. V. Gabaeva, V. E. Golimbet

https://doi.org/10.25557/2073-7998.2020.04.10-11

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Abstract

The study aimed to assess the contribution of haplotypes and polyenvironmental risk scores (PERS) to DNA methylation variability in schizophrenia index loci. In peripheral blood of 70 patients, fragments within the MIR137HR and CYP17A1 genes and near SLC39A8 were studied by Pacbio-based single-molecule real-time bisulfite sequencing. Of about 1000 cytosines, only eight were variably methylated. Genotypes influenced seven of them. Additionally, in one case an interaction effect of haplotype and PERS and in another case a main effect of PERS were found. Thus, in the studied schizophrenia loci, variable methylation is mainly due to DNA structure.