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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25557/2073-7998.2020.03.49-50</article-id><article-id custom-type="elpub" pub-id-type="custom">medgen-828</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF REPORT</subject></subj-group></article-categories><title-group><article-title>Коррекция эмбрионального кариотипа на преимплантационном этапе развития человека</article-title><trans-title-group xml:lang="en"><trans-title>Correction of the embryonic karyotype at the preimplantation stage of human development</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жигалина</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhigalina</surname><given-names>D. I.</given-names></name></name-alternatives><email xlink:type="simple">darya.zhigalina@medgenetics.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скрябин</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Skryabin</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Канбекова</surname><given-names>О. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Kanbekova</surname><given-names>O. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артюхова</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Artyukhova</surname><given-names>V. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Светлаков</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Svetlakov</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедев</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedev</surname><given-names>I. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Medical Genetics, Tomsk National Research Medical Center RAS</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Красноярский центр репродуктивной медицины, группа компаний «Мать и дитя»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Krasnoyarsk Center for Reproductive Medicine, MD Medical Group «Mother and Child»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>01</day><month>09</month><year>2020</year></pub-date><volume>19</volume><issue>3</issue><fpage>49</fpage><lpage>50</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Жигалина Д.И., Скрябин Н.А., Канбекова О.Р., Артюхова В.Г., Светлаков А.В., Лебедев И.Н., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Жигалина Д.И., Скрябин Н.А., Канбекова О.Р., Артюхова В.Г., Светлаков А.В., Лебедев И.Н.</copyright-holder><copyright-holder xml:lang="en">Zhigalina D.I., Skryabin N.A., Kanbekova O.R., Artyukhova V.G., Svetlakov A.V., Lebedev I.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/828">https://www.medgen-journal.ru/jour/article/view/828</self-uri><abstract><p>Сравнительное молекулярное кариотипирование внеклеточной ДНК из внутриполостной жидкости бластоцисты, а также эмбриобласта и трофэктодермы позволило получить свидетельства в пользу наличия механизмов самокоррекции эмбрионального кариотипа на преимплантационном этапе развития человека.</p></abstract><trans-abstract xml:lang="en"><p>Comparative molecular karyotyping of cell-free DNA from the blastocoele fluid of the blastocyst and the embryoblast and trophectoderm, allowed us to obtain evidence for the presence of mechanisms of self-correction of the embryonic karyotype at the preimplantation stage of human development.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бластоциста</kwd><kwd>самокоррекция эмбрионального кариотипа</kwd><kwd>анеуплоидия</kwd><kwd>внеклеточная ДНК</kwd><kwd>внутриполостная жидкость бластоцисты</kwd><kwd>blastocyst</kwd><kwd>self-correction of the embryonic karyotype</kwd><kwd>aneuploidy</kwd><kwd>cell-free DNA</kwd><kwd>blastocoele fluid</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
