medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.25557/2073-7998.2018.11.15-19medgen-598Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHПрогностическое значение кариотипа эмбриона и предыдущих исходов беременности при привычном невынашиванииPrognostic value of embryonic kariotypes and previous pregnancy outcomes in recurrent pregnancy lossНикитинаТ. В.NikitinaT. V.t.nikitina@medgenetics.ruСаженоваЕ. А.SazhenovaE. A.noemail@neicon.ruТолмачеваЕ. Н.TolmachevaE. N.noemail@neicon.ruСухановаН. Н.SukhanovaN. N.noemail@neicon.ruЖигалинаД. И.ZhigalinaD. I.noemail@neicon.ruМинайчеваЛ. И.MinaychevaL. I.noemail@neicon.ruЛебедевИ. Н.LebedevI. N.noemail@neicon.ruНаучно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр РАНРоссияResearch Institute of Medical Genetics, Tomsk National Research Medical CenterRussian Federation20180111201817111519Copyright © Никитина Т.В., Саженова Е.А., Толмачева Е.Н., Суханова Н.Н., Жигалина Д.И., Минайчева Л.И., Лебедев И.Н., 20182018Никитина Т.В., Саженова Е.А., Толмачева Е.Н., Суханова Н.Н., Жигалина Д.И., Минайчева Л.И., Лебедев И.Н.Nikitina T.V., Sazhenova E.A., Tolmacheva E.N., Sukhanova N.N., Zhigalina D.I., Minaycheva L.I., Lebedev I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/598

Привычное невынашивание беременности (ПНБ) - многофакторная патология, при которой заметная доля случаев имеет неустановленную этиологию. Сравнительный анализ частот аномальных кариотипов у погибших эмбрионов при первичном и вторичном ПНБ может пролить свет на генетическую гетерогенность данных групп. Целью работы явилось установление вклада хромосомных аномалий эмбриона в этиопатогенез первичного и вторичного ПНБ. Прокариотипировано 563 погибших эмбриона, из них 335 от женщин с первичным, и 228 - cо вторичным ПНБ. Частота хромосомных аберраций составила 43,9% и 52,6% в группах с первичным и вторичным ПНБ соответственно (p = 0,041). Двойные трисомии обнаружены у 5,2% абортусов, причем абсолютное их большинство выявлено в группе абортусов от матерей со вторичным ПНБ (p = 0,0002). Не обнаружено статистически значимых различий по частоте вовлеченности индивидуальных хромосом в анеуплоидии между группами с первичным и вторичным ПНБ. Частота хромосомных аномалий у абортусов выше при вторичном ПНБ, и эта разница обусловлена «нехваткой» эмбрионов с аномальными кариотипами у женщин старшего возраста с первичным ПНБ.

Recurrent pregnancy loss (RPL) is a multifactorial pathology with significant proportion of idiopathic cases. Comparative analysis of the chromosomal abnormalities rates in abortions in primary vs. secondary RPL can shed light on the genetic heterogeneity of these groups. The aim of this study was to establish the contribution of the embryonic chromosomal abnormalities in the pathogenesis of primary and secondary RPL. Of the 563 abortuses karyotyped, 335 were from women with primary and 228 with secondary RPL. The frequency of chromosomal aberrations was 43.9% and 52.6% in the groups with primary and secondary RPL, respectively (p = 0.041). Double trisomy were revealed in 5.2% of abortuses and the most of cases were found in secondary RPL group (p = 0.0002). There were no significant differences in the frequency of involvement of individual chromosomes in aneuploidy between groups with primary and secondary RPL. The frequency of aneuploid pregnancy significantly higher in secondary RPL, and this difference is due to the «lack» of abortuses with abnormal karyotypes in older women with primary RPL.

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The authors declare that there are no conflicts of interest present.